A new research undertaken by the Cochrane research group, based in Oxford, United Kingdom, and published in the Cochrane Library, has shown that ‘stem cell therapies work as a complement to standard treatments, potentially cutting the number of deaths after a year.’
The evidence from the latest Cochrane systematic review: ‘Stem cell therapy for chronic ischaemic heart disease and congestive heart failure’, suggests that “taking stem cells from a patient’s bone marrow and injecting them into their damaged heart may be an effective way to treat heart disease.”
Stem cell therapies are experimental treatments that are currently only available in facilities carrying out medical research. If eventually found to be effective, they might offer an alternative or complementary treatment to standard drug and surgical treatments for some patients with chronic heart disease.
The procedure involves collecting stem cells from a patient’s own blood or bone marrow, and using them to repair damaged tissues in the patient’s heart and arteries.
The new review, published in The Cochrane Library, an electronic database of hundreds of thousands of health research findings from around the world, used data involving 1,255 people from 23 randomised controlled trials, where all participants received standard treatments.
Compared to standard treatment alone or with placebo, stem cell therapy using bone marrow cells resulted in fewer deaths due to heart disease and heart failure, reduced the likelihood of patients being readmitted to hospital, and improved heart function.
Enca Martin-Rendon, author of the review, of the Cochrane Heart Review Group, and based at the NHS Blood and Transplant and the University of Oxford, UK, said: “This is encouraging evidence that stem cell therapy has benefits for heart disease patients. However, it is generated from small studies, and it is difficult to come to any concrete conclusions until larger clinical trials that look at longer-term effects are carried out.”
However, researchers say that with much larger clinical trials underway, the findings are awaited to enable more certainty about the effects.
Although within the first year, there were no clear benefits of stem cell therapy over standard treatment alone, when longer term data were analysed a year or more later about 3 per cent of people treated with their stem cells had died, compared with 15 per cent of people in the control groups.
Hospital readmissions were reduced to two in every 100 people, compared to nine in the control group, and adverse effects were rare.
Martin-Rendon continued, “It isn’t clear which types of stem cells work best or why stem cell therapies seem to work for some people but not for others. We need to find out what is different in the people who aren’t responding well to these treatments, as it might then be possible to tailor therapies to these patients, so that they work better.”
David Tovey, the Editor-in-Chief of Cochrane Library, said: “This review should help to raise awareness of the potential of stem cell therapy to improve patient outcomes, but it also demonstrates the importance of recognising the uncertainty of initial findings, and the need for further research.
“A Cochrane review aims to analyse all available data to give a clear picture of what the evidence shows. Ensuring health decision makers, health professionals and the general public has access to up-to-date, relevant evidence research will help to raise awareness of the effectiveness of treatments and medications, and therefore improve health care.”
BEN EGUZOZIE
Join BusinessDay whatsapp Channel, to stay up to date
Open In Whatsapp
